Thomas Grigliatti

  • Office phone
  • Research area
    Cell and Developmental Biology
  • History

    B.Sc., Santa Clara; M.S., California State (San Francisco); Ph.D., U.B.C.; Member, Nat'l Centres of Excellence Insect Biotec. Lab.; Associate Member, Medical Genetics Dept., U.B.C.; President, Genetics Society of Canada 1993-95

Genes that encode non-histone chromosomal proteins:The modulation of chromatin domains is the first step in the regulation of gene expression in eukaryotes. Yet the assembly of DNA and proteins into active and inactive chromatin, and into chromosomes, is a process about which we know very little. We have isolated mutations in Drosophila that actually alter both chromosome and chromatin structure and consequently also regulate gene expression and developmental switches. Many of these genes are conserved in vertebrates. We are focussing our current work on the molecular analyses of these genes and their products including DNA sequence analysis, cellular and developmental expression of theprotein products, dissecting the hierarchy of gene action and protein interactions in the assembly of chromatin in vivo.

2011-2012 Distinguished Scholar in Residence Award

For Research

Based on recognized research excellence

Molecular and developmental analysis of cdc 2 mutations in Drosophila melanogaster
Genome 36:676-685
Clegg, N.S., I.P. Whitehead, J. Williams, M. O'Grady, G.P. Spiegelman & T.A. Grigliatti
Rapid spread of a P element/ Pdh Gene construct through populations of Drosophila melangaster
Meister, G.A. & T.A. Grigliatti
A rapid somatic genotoxicity assay in Drosophila melanogaster using multiple mutant mutagen - sensitivity (mus) strains
Mutagenesis 7: 399-406
Henderson, D. & T.A. Grigliatti
Position-effect Variegation: An Assay for Non-histone Chromosomal Proteins and Chromatin Assembly and Modifying Factors
Functional Organization of the Nucleus pp. 587-627
Grigliatti, T.A
Suppressors of position effect variegation alter chromosome and chromatin structure
Chromosoma 99: 391-400
Hayashi, S., A. Ruddell, D. Sinclair & T.A. Grigliatti
Rapid spread of transposable P elements in experimental populations of Drosophila melanogaster
Genetics, 112: 387-396
Good, A.G., G. Meister, H. Brock, T.A. Grigliatti & D.A. Hickey
The evolution of P transposable elements: Sequences of the Drosophila nebulosa P element
Proc. Natl. Acad. Sci., U.S.A. 84: 6491-6495
Lansman, R.A., R.O. Shade, T.A. Grigliatti & H.W. Brock