Matthew Taves

I am interested in the interactions between glucocorticoids (steroid stress hormones) and the immune system. These hormones have powerful immunosuppressive effects, which are thought to prevent harmful overshoot of the immune response. Immature lymphocytes (a type of white blood cell) are especially vulnerable to glucocorticoids. Paradoxically, it appears that immune organs may produce their own glucocorticoids in early life, when the majority of lymphocyte development is occurring. My research aims to determine if glucocorticoids are locally produced in immune organs, how their production is regulated, and what role they play.

CIHR CGS-D

2010
/
For Research
Matthew Taves

CIHR CGS-M

2009
/
For Research
Matthew Taves
High cortisol levels in lymphoid organs of the developing zebra finch but not Japanese quail or chicken
Developmental & Comparative Immunology 54:116-125
Taves MD, Losie JA, Rahim T, Schmidt KL, Sandkam BA, Ma C, Silversides F, Soma KK
2016
Colony specific differences in endocrine and immune responses to an inflammatory challenge in female Sprague-Dawley rats
Endocrinology (In press)
Bodnar TS, Hill LA, Taves MD, Yu W, Soma KK, Hammond GL, Weinberg J
2015
Neuronal gonadotropin-releasing hormone (GnRH) and astrocytic gonadotropin inhibitory hormone (GnIH) immunoreactivity in the adult rat hippocampus
Journal of Neuroendocrinology 27:772-786
Ferris JK, Tse MT, Hamson DK, Taves MD, Ma C, McGuire N, Arckens L, Bentley GE, Galea LAM, Floresco SB, Soma KK
2015
Steroid profiling reveals widespread local regulation of glucocorticoids during mouse development
Endocrinology 156:511-522
Taves MD, Plumb AW, Sandkam BA, Ma C, Van Der Gugten JG, Holmes DT, Close DA, Abraham N, Soma KK
2015
Effects of nutritional stress during different developmental periods on song and the hypothalamic-pituitary-adrenal axis in zebra finches
Hormones and Behavior 65: 285-293
Kriengwatana B, Wada H, Schmidt KL, Taves MD, Soma KK, MacDougall-Shackleton SA
2014
Greater sensitivity to novelty in rats is associated with increased motor impulsivity following repeated exposure to a stimulating environment: implications for the etiology of impulse control deficits
European Journal of Neuroscience 40:3746-3756
Ferland JMN, Zeeb FD, Yu K, Kaur S, Taves MD, Winstanley CA
2014
Sex steroid levels and AD-like pathology in 3xTgAD mice
Journal of Neuroendocrinology 25:131-144
Overk CR, Perez SE, Ma C, Taves MD, Soma KK, Mufson EJ
2013
Behavior as biomarker? Laboratory versus field movement in round goby (Neogobius melanostomus) from highly contaminated habitats
Ecotoxicology. 21:1003-1012
Marentette JR, Tong S, Wang G, Sopinka NM, Taves MD, Koops M, Balshine S
2012
Soft song during aggressive interactions: seasonal changes and endocrine correlates in song sparrows
Hormones and Behavior 62:455-463
Maddison CJ, Anderson RA, Prior NH, Taves MD, Soma KK
2012
Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function
American Journal of Physiology - Endocrinology and Metabolism 301:E11-E24
Taves MD, Gomez-Sanchez CE, Soma KK
2011