Hugh W. Brock


I have closed my laboratory and am now working in the office of the Provost, so I am no longer accepting students for coop, directed studies, volunteer, honours theses, or graduate school.

  • Office phone
  • Research area
    Cell and Developmental Biology
  • History

    Director of the Genetics Graduate Program; B.Sc., U.B.C.; D.Phil., Oxford; EMBO Post-doctoral Fellow, Univ of Paris (1981); Jane Coffin Childs Fellow, Univ. of Washington (1981); Associate Member, Medical Genetics Dept., UBC; Associate Member, Biotechnology Lab., UBC; President of the Genetics Society of Canada 2002-2003.

Killam Teaching Award

For Teaching
Transcription-independent function of Polycomb group protein PSC in cell cycle control
Science 336: 744-7
Mohd-Sarip, A., Lagarou, A., Doyen, C.M., van der Knaap, J.A., Aslan, U., Bezstarosti, K., Yassin, Y., Brock, H.W., Demmers, J.A., C.P. Verrijzer
TrxG and Pcg proteins but not methylated histones remain associated with their response elements during DNA replication
Cell 150:922-33
Petruk, S., Johnston, D.M., Sedkov, Y., Hodgson, J.W., Black, K.L., Beck, S., Cananni, E., Brock, H.W., A. Mazo
Are Polycomb Group bodies gene silencing factories
Cell 144: 170-171
Hodgson, J.W., H.W. Brock
Additional sex combs-like 1 belongs to the enhancer of trithorax and Polycomb Group and genetically interacts with Cbx2 in mice
Developmental Biology 337, 9-15
Fisher, C.L. Lee, I., Komljenovic, I., Bozza, S., Pineault, N. ,Bloyer, S., Brookes, C., Chevalier, J., Dahl, A, Helgason, C., Hess, J.L., Humphries, R.K., and Brock, H.W
Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint
Dev. Biol. 339:320-328
Beck, S.A., O’Dor, E., Catching, A., Brock, H.W
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
Blood 115:38-46
Fisher CL, Pineault N, Brookes C, Helgason CD, Ohta H, Bodner C, Hess JL, Humphries RK, Brock HW
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc)
Proc. Natl. Acad. Sci USA 106,13427-13432
Sinclair, D.A.R., Syrzycka. M., Macauley, M. Rastgardani, T. , Komljenovic, I. , Vocadlo, D., Brock, H.W., Honda, B
Regulatory non-coding RNAs at Hox loci
Biochem. Cell Biol. 8,:27-34
Brock, H.W., Hodgson, J.W., Petruk, S., and Mazo, A
Isolation and characterization of a novel H1 2 complex that acts as a repressor of p53-mediated transcription
J. Biol. Chem. 283, 9113-9126
Kim, K, Choi, J., Kim, H. Levens, D., Kohno, K., Johnson, E.M., Brock, H.W., An, W
The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein
Proc. Natl. Acad. Sci USA 105, 12405-12410
Hallson, G. Syrzycka, M., Beck, S.A., Kennison, J.A., Dorsett, D., Page, S.L., Hunter, S.M., Keall, R., Warren, W.D., Brock, H.W., Sinclair, D.A.R., and Honda, B.M