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Preprints (in review)

Metzger DCH (2023) Responses and adaptations to the environment: epigenetic mechanisms in response to environmental change. Encyclopedia of Fish Physiology, Second Edition.

Metzger DCH, Porter I, Sandkam BA, Fong LJM, Mank JE (2022) Transposon wave remodelled the epigenomic landscape in the rapid evolution of a novel X chromosome dosage compensation mechanism. bioRxiv. https://biorxiv.org/cgi/content/short/2022.09.29.510218v1

Metzger DCH & Mank JE (2020) Conserved sex-biased DNA methylation patterns target key developmental genes and non-recombining region of the guppy sex chromosome. bioRxiv.  https://doi.org/10.1101/2020.08.21.261792

Published manuscripts

Fong LJM, Darolti I, Metzger DCH, Morris J, Lin Y, Sandkam BA, Mank JE (2023) Parsimony and poeciliid sex chromosome evolution. Genome Biology and Evolution, 15(9), evad128.

https://doi.org/10.1093/gbe/evad128

Darolti I, Fong LJM, Sandkam BA, Metzger DCH, Mank JE (2023) Sex chromosome heteromorphism and the Fast-X effect in poeciliids. Molecular Ecology, 32, 4599–4609. https://doi.org/10.1111/mec.17048

Fong LJM, Darolti I, Metzger DCH, Morris J, Lin Y, Sandkam BA, Mank JE (2023) Evolutionary history of the Poecilia picta sex chromosomes. Genome Biology and Evolution, 15(3), evad030. https://doi.org/10.1093/gbe/evad030

Metzger DCH, Sandkam BA, Darolti I, Mank JE (2021) Rapid evolution of complete dosage compensation in Poecilia. Genome Biology and Evolution, 13(7), evab115. https://doi.org/10.1093/gbe/evab155

Furman BL, Metzger DCH, Darolti I, Wright AE, Sandkam BA, Almeida P, Shu JJ, Mank JE (2020) Sex chromosome evolution: so many exceptions to the rules. Genome Biology and Evolution, 12(6), 750-63. https://doi.org/10.1093/gbe/evaa081

Metzger DCH, Schulte PM (2018) Similarities in temperature-dependent gene expression plasticity across time scales in threespine stickleback (Gasterosteus aculeatus). Molecular Ecology, 27(10), 2381-2396. https://doi.org/10.1111/mec.14591

Metzger DCH, Schulte PM (2018) The DNA methylation landscape of stickleback reveals patterns of sex chromosome evolution and effects of environmental salinity. Genome Biology and Evolution, 10(3), 775-785. https://doi.org/10.1093/gbe/evy034

Harter TS, Sackville MA, Wilson JM, Metzger DCH, Egginton S, Esbaugh AJ, Farrell AP Brauner CJ (2018) A solution to Nature’s haemoglobin knockout: a plasma-accessible carbonic anhydrase catalyses CO₂ excretion in Antarctic icefish gills. Journal of Experimental Biology, 221(22). https://doi.org/10.1242/jeb.190918

Metzger DCH, Schulte PM (2017) Persistent and plastic effects of temperature on DNA methylation across the genome of threespine stickleback (Gasterosteus aculeatus). Proceedings of the Royal Society of London B, 284(1864), 20171667. https://doi.org/10.1098/rspb.2017.1667

Gibbons TC, Metzger DCH, Healy TM, Schulte PM (2017) Gene expression plasticity in response to salinity acclimation in threespine stickleback ecotypes from different salinity habitats. Molecular Ecology, 26(10), 2711-2725. https://doi.org/10.1111/mec.14065

(Metzger DCH, Schulte PM (2016) Maternal stress has divergent effects on gene expression patterns in the brains of male and female threespine stickleback. Proceedings of the Royal Society of London B, 283(1839), 20161734. https://doi.org/10.1098/rspb.2016.1734

Metzger DCH, Healy TM, Schulte PM (2016) Conserved effects of salinity acclimation on thermal tolerance and hsp70 expression in divergent populations of threespine stickleback (Gasterosteus aculeatus). Journal of Comparative Physiology B, 186(7), 879-889. https://doi.org/10.1007/s00360-016-0998-9

Metzger DCH, Schulte PM (2016) Epigenomics in marine fishes. Marine Genomics, 30, 43-54. https://doi.org/10.1016/j.margen.2016.01.004

Metzger DCH, Hemmer-Hansen J, Schulte PM (2016) Conserved structure and expression of hsp70 paralogs in teleost fishes. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 18, 10-20. https://doi.org/10.1016/j.cbd.2016.01.007

Timmins‐Schiffman EB, Friedman CS, Metzger DC, White SJ, Roberts SB (2013) Genomic          resource development for shellfish of conservation concern. Molecular Ecology Resources, 13(2), 295-305. https://doi.org/10.1111/1755-0998.12052

Metzger DC, Luckenbach JA, Dickey JT, Park LK, Beckman BR (2013) Development of a multiplex gene expression assay for components of the endocrine growth axis in Coho salmon, General and Comparative Endocrinology. 189, 134-140. https://doi.org/10.1016/j.ygcen.2013.04.022

Metzger DC, Pratt P, Roberts SB (2012) Characterizing the effects of heavy metal and Vibrio exposure on hsp70 expression in Crassostrea gigas. Journal of Shellfish Research, 31(3), 627-630.  https://doi.org/10.2983/035.031.0305

Metzger DC, Luckenbach JA, Shimizu M, Beckman BR (2012) Normalizing for biology: accounting for technical and biological variation in levels of reference gene and insulin-like growth factor 1 (igf1) transcripts in fish livers. Comp Biochem Physiol B, 163(1), 7-14. https://doi.org/10.1016/j.cbpa.2012.04.014

Metzger DC, Elliott DG, Wargo A, Park LK, Purcell MK (2010) Pathological and immunological responses associated with differential survival of Chinook salmon following Renibacterium salmoninarum challenge. Dis Aquat Org, 90(1), 31-41. https://doi.org/10.3354/dao02214

Liu R, Woolner S, Johndrow JE, Metzger D, Flores A, Parkhurst SM (2008) Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos. Development, 135(1): 53-63. https://doi.org/10.1242/dev.011437

Orian A, Delrow JJ, Rosales Nieves AE, Abed M, Metzger D, Paroush Z, Eisenman RN, Parkhurst SM (2007) A Myc–Groucho complex integrates EGF and Notch signaling to regulate neural development. PNAS, 104:15771-15776. https://doi.org/10.1073/pnas.0707418104