Consider the genotype of the developing individual. When the zygote is first formed, it has its original genotype (call this the non-mutant). Every cell division, there is a chance that a mutation will occur. Ignore back-mutations.
Write down the frequency of non-mutant and mutant cells as a function of the number of cell divisions since zygote formation, t.
In an organism that undergoes 100 cell divisions during development, what fraction of the cells will be mutant at a particular gene at the end of development if equals 10-7 per cell division?
Across an entire genome of 105 genes, would be approximately 10-2 per cell division. What fraction of cells in the adult will carry a mutant gene somewhere in the genome?