Receptors that are not specifically retrieved from early endosomes are transferred to lysosomes and degraded

Retreived receptors are returned either to the membrane domain of origin (recycling) or to another domain (transcytosis).  If the ligand bound to the receptor stays bound in the acidic environment of the endosome, it will follow the same pathway as the receptor, otherwise it will be transferred to a lysosome and degraded.

Fig. 14-30