The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in MET_HUMAN the hepatocyte growth factor receptor and PLX4_HUMAN.
INTERPRO description (entry IPR001627)
The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in a hepatocyte growth factor receptor, in SEX protein PUBMED:9875845 and in viral proteins.
CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity. CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down- regulates B cell expression of CD23.
CD molecules are leucocyte antigens on cell surfaces. CD antigen nomenclature is updated at http://mpr.nci.nih.gov/prow/.