Accession number: PF01414
Delta serrate ligand
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<IMG src='gif/DSL.gif'>
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Description
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Ligands of the Delta/Serrate/lag-2 (DSL) family and their receptors, members of the lin-12/Notch family, 
mediate cell-cell interactions that specify cell fate in invertebrates and vertebrates. In C. elegans, 
two DSL genes, lag-2 and apx-1, influence different cell fate decisions during development. . Molecular 
interaction between Notch and Serrate, another EGF-homologous transmembrane protein containing a region 
of striking similarity to Delta, has been shown and the same two EGF repeats of Notch may also constitute 
a Serrate binding domain.
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<IMG src='gif/DSL2.gif'>
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Description text from InterPro entry IPR001774 
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References:
1.
Notch signaling.
Artavanis-Tsakonas S, Matsuno K, Fortini ME;
Science 1995;268:225-232.
2.
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.
Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S;
Cell 1991;67:687-699.
3.
Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo.
Fitzgerald K, Greenwald I;
Development 1995;121:4275-4282.
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Also see lag-2:
<A HREF='http://www.wormbase.org/db/gene/gene?name=lag-2'>http://www.wormbase.org/db/gene/gene?name=lag-2</A>
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From Cytokines Online: 
<A HREF='http://www.copewithcytokines.de/cope.cgi?3051'>http://www.copewithcytokines.de/cope.cgi?3051</A>
<P><u>DSL</u>
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an abbreviation derived from Delta (delta-1 ), Serrate (jagged-1 ), and Lag-2 , all of which have been shown to function as ligands for the Notch protein, thereby regulating the differentiation of many different cell types during metazoan development.
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DSL proteins are characterized by the presence of a unique and conserved DSL sequence motif and also contain a variable number of tandemly repeated copies of an EGF-like repeats .
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The lin-12 gene found in the nematode Caenorhabditis elegans has been shown to encode a member of the Notch family of proteins.
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Date of last revision: January 2002
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References: Lissemore JL and Starmer WT Phylogenetic analysis of vertebrate and invertebrate Delta/Serrate/LAG-2 (DSL) proteins. Molecular Phylogenetics and Evolution 11(2): 308-19 (1999) 
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Also see Notch signalling pathway diagram at:
<A HREF='http://www.biochem.northwestern.edu/holmgren/Glossary/Models/Notch_signaling.htm'>http://www.biochem.northwestern.edu/holmgren/Glossary/Models/Notch_signaling.html</A>